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Synthesis of α‐Cyclodextrin‐Conjugated Poly( ε ‐lysine)s and Their Inclusion Complexation Behavior
Author(s) -
Huh Kang Moo,
Tomita Hajime,
Lee Won Kyu,
Ooya Tooru,
Yui Nobuhiko
Publication year - 2002
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/1521-3927(20020201)23:3<179::aid-marc179>3.0.co;2-u
Subject(s) - cyclodextrin , lysine , conjugated system , inclusion compound , chemistry , polymer , aqueous solution , polymer chemistry , molecule , biodegradation , drug delivery , side chain , combinatorial chemistry , organic chemistry , amino acid , biochemistry
Novel functional polymers utilizing specific host/guest interactions were designed by introducing α ‐CD host molecules into poly( ε ‐lysine) chains as side groups. An interesting phase separation was observed as a result of the inclusion complexation between the polymeric host and 3‐(trimethylsilyl)propionic acid as a model guest in aqueous media. This water‐soluble polymeric host would be useful for various applications, particularly drug delivery, due to its biodegradability, low toxicity, and unique functionality represented as a complexation‐induced phase separation.