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Grafting of ω ‐Functionalized PVP Oligomers onto Dextran: A Novel Route to Biodegradable and Biocompatible Polymers
Author(s) -
Brunius Carl F.,
Ranucci Elisabetta
Publication year - 2001
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/1521-3927(20011201)22:18<1474::aid-marc1474>3.0.co;2-7
Subject(s) - grafting , dextran , copolymer , polymer chemistry , polymer , solubility , biocompatible material , polymerization , materials science , chemical engineering , chemistry , organic chemistry , biomedical engineering , medicine , engineering
ω ‐Hydroxy‐functionalized oligo( N ‐vinyl‐2‐pyrrolidinone) (PVPOH) was prepared by chain‐transfer radical polymerization in the presence of 2‐isopropoxyethanol as the chain‐transfer agent, and grafted onto dextran. Two PVP‐Dex graft copolymers were obtained starting from different PVPOH/dextran weight ratios in the feed, namely 2 : 1 and 5 : 1. The variation of molecular weight distributions, combined with the results of solubility tests and of selective extractions in organic solvents, irrefutably confirmed the successful grafting reactions and the efficacy of the purification procedures applied.