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N ‐Isopropylacrylamide Copolymers with Acrylamide and Methacrylamide Derivatives of Cholic Acid: Synthesis and Characterization
Author(s) -
Liu Huiyou,
Avoce Damien,
Song Zhengji,
Zhu X. X.
Publication year - 2001
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/1521-3927(20010601)22:9<675::aid-marc675>3.0.co;2-c
Subject(s) - lower critical solution temperature , methacrylamide , copolymer , cholic acid , polymer chemistry , polymerization , differential scanning calorimetry , acrylamide , chemistry , polymer , materials science , organic chemistry , bile acid , biochemistry , physics , thermodynamics
By free radical polymerization, we have prepared a series of water‐soluble, thermosensitive copolymers based on N ‐isopropylacrylamide and (meth)acrylamide derivatives of cholic acid, one of the bile acids. The copolymers contained 1–7 mol‐% of the (meth)acrylamide derivatives of cholic acid. The chemical composition in the copolymers was studied by NMR spectroscopy and was found to be close to the original composition of the comonomers in the feed prior to polymerization. The lower critical solution temperatures (LCST) of the polymer solutions were measured by means of differential scanning calorimetry and turbidimetry. The resulting copolymers exhibit systematic changes in their LCSTs as a function of their chemical composition, as the incorporation of hydrophobic comonomers leads to a lower LCST.