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Novel Thermoreversible Gelation of Biodegradable PLGA‐ block ‐PEO‐ block ‐PLGA Triblock Copolymers in Aqueous Solution
Author(s) -
Lee Doo Sung,
Shim Myung Seob,
Kim Sung Wan,
Lee Hyunjung,
Park Insun,
Chang Taihyun
Publication year - 2001
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/1521-3927(20010501)22:8<587::aid-marc587>3.0.co;2-8
Subject(s) - copolymer , micelle , ethylene oxide , aqueous solution , plga , materials science , polymer chemistry , glycolic acid , oxide , chemical engineering , chemistry , lactic acid , organic chemistry , polymer , nanotechnology , nanoparticle , composite material , engineering , biology , bacteria , metallurgy , genetics
The BAB‐type triblock copolymers composed of a central poly(ethylene oxide) (PEO, M̄ nPEO = 1 000) block and two poly[( D , L ‐lactic acid)‐ co ‐(glycolic acid)] end blocks with molecular weights between 900 and 1 600 exhibited an interesting phase transition behavior. The copolymer aqueous solution can form micelles with PLGA loops in the core and a PEO shell and groups of micelles because of bridging between micelles caused by the PLGA blocks with raising temperature. A possible micellar gelation mechanism was suggested.