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Syntheses, electrochemistry and cytotoxicity of ferrocene‐containing polyaspartamides as water‐soluble polymeric drug carrier/drug conjugates
Author(s) -
Swarts J.C.
Publication year - 2002
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200208)186:1<123::aid-masy123>3.0.co;2-2
Subject(s) - conjugate , cytotoxicity , drug , drug carrier , combinatorial chemistry , ferrocene , chemistry , electrochemistry , drug delivery , nanotechnology , pharmacology , materials science , organic chemistry , in vitro , biochemistry , medicine , electrode , mathematical analysis , mathematics
A general strategy towards the syntheses of water‐soluble polymeric drug carriers and their drug conjugates is described. Methods of drug uptake by cells, drug release from the polymeric carrier and the relevance of electrochemistry to drug activity of the ferrocenyl group are highlighted. The advantages of these polymeric systems are demonstrated utilising cytotoxicity results of a polyaspartamide‐ferrocenyl conjugate.