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Gadolinium diethylenetriaminepentaacetic acid hyaluronan conjugates: preparation, properties and applications
Author(s) -
Gouin Sébastien,
Grayeb M. Victoria Valencia,
Winnik Françoise M.
Publication year - 2002
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200208)186:1<105::aid-masy105>3.0.co;2-2
Subject(s) - gadolinium , ethylenediamine , diethylenetriaminepentaacetic acid , conjugate , chemistry , covalent bond , aqueous solution , polymer , hyaluronic acid , carboxylic acid , nuclear chemistry , chelation , polymer chemistry , combinatorial chemistry , organic chemistry , mathematical analysis , mathematics , biology , genetics
We have prepared new hyaluronan (HA) gadolinium diethylenetriaminepentaacetic acid (DTPA) conjugates that have potential as tumor specific contrast agents for magnetic resonance imaging. Conjugates were synthesized, starting with a high molecular weight HA or with HA oligomers, by an efficient 2‐step procedure involving first, reaction of ethylenediamine with HA carboxylic acid groups and, second, covalent linkage of DTPA to aminated HA. The final polymers were compared in terms of molar masses and DTPA content. Tapping mode atomic force microscopy has been used to examine the morphology of the polymers in aqueous solution.