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Hydrophilic stimuli‐responsive particles for biomedical applications
Author(s) -
Pichot C.,
Elaïssari A.,
Duracher D.,
Meunier F.,
Sauzedde F.
Publication year - 2001
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200110)175:1<285::aid-masy285>3.0.co;2-d
Subject(s) - materials science , polystyrene , nucleation , chemical engineering , particle (ecology) , particle size , colloid , polymer , polymer chemistry , nanotechnology , chemistry , organic chemistry , composite material , oceanography , engineering , geology
Hydrophilic and stimuli‐responsive submicronic latex particles based on polyalkyl(meth)acrylamide can be prepared owing to simple radical‐initiated polymerizations in heterogeneous media using a water‐soluble initiator and a crosslinker (methylenebisacrylamide). The paper aims at reviewing the synthesis and properties of functionalized polystyrene‐polyN‐isoprpylacrylamide core‐shell particles or polyN‐isopropylmethacrylamide microgel particles. Particle size of analysis showed that a short nucleation period afforded the synthesis of highly monodispersed latexes. The dramatic change of the colloidal properties (particle size, electrophoretic mobility) was found to reflect the thermal sensitivity of such particles. The hydrophilic nature of the particles below the volume phase transition temperature was found to drastically reduce the physical adsorption of proteins. Some examples of biomedical applications of these stimuli‐responsive particles are briefly reported.