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Stereocomplexes, based on biodegradable polymers and bioactive macromolecules
Author(s) -
Slager Joram,
Gladnikoff Micha,
Domb Abraham J.
Publication year - 2001
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200110)175:1<105::aid-masy105>3.0.co;2-c
Subject(s) - crystallinity , polymer , enantiomer , macromolecule , peptide , materials science , polymer chemistry , in vivo , chemistry , chemical engineering , crystallography , organic chemistry , composite material , biochemistry , engineering , microbiology and biotechnology , biology
Stereocomplexation between two enantiomeric polymers such as D‐PLA and L‐PLA have been described in the literature. No reports up till now have been published on the complexation between two non‐identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X‐ray) without any irriversibility. DSC‐scans show an additional signal related to the second (β‐) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D‐PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in‐vitro . In‐vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH.