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Hydrogels for encapsulation of mammalian cells
Author(s) -
Lukáš Jaromír,
Palečková Věra,
Mokrý Jaroslav,
Karbanová Jana,
Dvořánková Barbora
Publication year - 2001
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200107)172:1<157::aid-masy157>3.0.co;2-k
Subject(s) - copolymer , self healing hydrogels , methacrylate , cell encapsulation , polyelectrolyte , swelling , polymer chemistry , materials science , alkyl , chemical engineering , chemistry , polymer , organic chemistry , composite material , engineering
In our attempt to prepare new hydrogels for cell encapsulation, we decided to use synthetic copolymers presuming that chemical bonds should bring better mechanical stability of capsules than electrostatic forces between polyanions and polycations in the so far predominantly used materials based on polyelectrolyte complexes. Two series of copolymers of 2‐hydroxyethyl methacrylate (HEMA) with alkyl acrylates (methacrylates) or N ‐alkylacrylamides (methacrylamides) were prepared. The copolymers, prepared by solution copolymerization in ethanol, were characterized by swelling in water and PBS solution, viscometric molecular weight, and NMR analysis, and their encapsulation processability was tested. Their characteristics and the first biological tests are the subject of this paper.