Premium
Sulfonamide‐containing polymers: a new class of pH‐sensitive polymers and gels
Author(s) -
Kang Seong Il,
Na Kun,
Bae You Han
Publication year - 2001
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200107)172:1<149::aid-masy149>3.0.co;2-g
Subject(s) - polymer , nanoparticle , copolymer , aqueous solution , smart polymer , chemical engineering , drug delivery , sulfapyridine , chemistry , materials science , polymer chemistry , nanotechnology , organic chemistry , engineering
New pH‐responsive polymers and hydrogel nanoparticles were synthesized, which bear either sulfapyridine or sulfamethoxypyridazine. The linear copolymers in water showed soluble/insoluble transition, while the hydrogel nanoparticles in aqueous solutions experienced association/dissociation transition in a narrow pH range. Their pH sensitivity was confirmed by the change in turbidity or particle size as a function of pH. The ionization of SO 2 NH group in sulfonamides is responsible for aggregation of the polymers or hydrogel nanoparticles. The transition pH is determined by the amount of SO 2 NH groups in the copolymers or on the hydrogel nanoparticle surface; at an optimum composition, the transitions occur near physiological pH. These systems may present a potential for various biomedical and bioengineering fields, such as pulsatile drug delivery, targeting, embolization, sensors, and bioseparation.