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Reactive hydrogels grafted on gold surfaces
Author(s) -
Laschewsky André,
Ouari Olivier,
Mangeney Claire,
Jullien Ludovic
Publication year - 2001
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200102)164:1<323::aid-masy323>3.0.co;2-9
Subject(s) - monomer , photopolymer , materials science , surface modification , copolymer , self healing hydrogels , surface plasmon resonance , polymer chemistry , grafting , colloidal gold , biochip , acrylamide , polymer , chemical engineering , combinatorial chemistry , chemistry , nanotechnology , nanoparticle , engineering , composite material
Three different strategies for the fixation of stable hydrogel coatings on gold surfaces, by the grafting‐to and grafting‐from techniques, are described. Monomeric or polymeric disulfide initiators are employed to start the photopolymerization of N‐[tris(hydroxy‐methyl)methyl]acrylamide 1 via decomposition of azo compounds or via a photoredox system. Different approaches, based on the post functionalization of the poly(1) films or on copolymerization of reactive monomers with 1 , are employed to bind potential receptor molecules bearing amino or thiol groups as anchor to the hydrogel. Thus, the functionalized coatings should allow the selective binding of particular analyzates. The overall goal is focused on hydrogel films for the preparation of biochips used in analytical devices such as Surface Plasmon Resonance (SPR), though our approach seems to be generally useful for related purposes.