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Sequence design of biomimetic copolymers: modeling of membrane proteins and globular proteins with active enzymatic center
Author(s) -
Chertovich A.V.,
Ivanov V.A.,
Lazutin A.A.,
Khokhlov A.R.
Publication year - 2000
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200010)160:1<41::aid-masy41>3.0.co;2-i
Subject(s) - copolymer , monomer , monte carlo method , globular protein , membrane , sequence (biology) , chemistry , chain (unit) , materials science , biological system , crystallography , physics , polymer , biochemistry , organic chemistry , biology , mathematics , statistics , astronomy
The biomimetic approach to the sequence design of synthetic AB‐copolymers has been developed further by means of new series of Monte Carlo computer simulation. The approach is based on using of some particular conformation of a homopolymer chain for “coloring” of monomeric units into two “colors” (or types) A and B depending on the spatial position of particular monomeric unit. We present recent data of our Monte Carlo computer simulation studies of properties of designed AB‐copolymers which mimic membrane proteins, and designed ABC‐copolymers which mimic proteins with active enzymatic center. We have found further evidences for the fact that designed copolymer chain preserves the “memory” about its “parent” spatial conformation and shows the well‐pronounced tendency to restore main features of the “parent” conformation.