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Controlled ring‐opening polymerization of lactones and lactides
Author(s) -
Albertsson AnnChristine,
Edlund Ulrica,
Stridsberg Kajsa
Publication year - 2000
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200007)157:1<39::aid-masy39>3.0.co;2-1
Subject(s) - copolymer , materials science , polymerization , crystallinity , polymer , biodegradable polymer , drug delivery , elastomer , polyester , biodegradation , ring opening polymerization , solubility , polymer chemistry , controlled release , chemical engineering , polymer science , organic chemistry , chemistry , nanotechnology , composite material , engineering
Abstract 1,5‐dioxepan‐2‐one (DXO) is presented as a versatile component in biodegradable polymers for biomedical applications. Copolymerization of DXO and L‐lactide yielded a semi‐crystalline, yet flexible, material where the extent of crystallinity and erosion characteristics were controlled by an appropriate choice of copolymer composition. Crosslinked PDXO was polymerized as a novel biodegradable elastomer. The degradation behavior of these materials were explored in vitro . Microspheres from poly(DXO‐co‐L‐LA) were prepared and shown to be promising candidates for controlled release. The polymer composition and drug solubility provided effective means of controlling the drug delivery pattern.