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Metal‐ion complexes in the angiogenetic effect
Author(s) -
Barbucci Rolando,
Magnani Agnese
Publication year - 2000
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/1521-3900(200007)156:1<239::aid-masy239>3.0.co;2-j
Subject(s) - polysaccharide , aqueous solution , metal , metal ions in aqueous solution , hyaluronic acid , chemistry , stoichiometry , adhesion , inorganic chemistry , derivative (finance) , organic chemistry , biology , genetics , financial economics , economics
The complex formation between two polysaccharides, hyaluronic acid (Hyal) and its sulphated derivative (HyalS), and two metal ions, Cu 2+ and Zn 2+ was investigated in aqueous solution by thermodynamic and spectroscopic techniques. A stoichiometry for the complex species in solution was obtained. The bioactivity of the metal‐polysaccharide complexes was then evaluated in terms of their influence on endothelial cell migration and adhesion. The biological response of the complex species was found to be dependent of both the polysaccharide (Hyal or HyalS) and the metal ion (Cu 2+ or Zn 2+ ).