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Copper‐Catalyzed Reductive Alkylations of Enones: A Novel Transmetalation Protocol
Author(s) -
Lipshutz Bruce H.,
Papa Patrick
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021202)41:23<4580::aid-anie4580>3.0.co;2-7
Subject(s) - transmetalation , borane , chemistry , catalysis , hydroboration , boron , protocol (science) , organic chemistry , combinatorial chemistry , medicine , alternative medicine , pathology
Looking for an alternative to prepare your regio‐ and stereodefined boron enolates? Concerned about using expensive and moisture‐sensitive Bu 2 BOTf? Consider this new procedure for regiospecific enolization based on a catalytic CuH‐initiated 1,4‐reduction followed by in situ transmetalation with a simple borane (R $\rm{^{{\prime}}_{{2}}}$ BH; see scheme).