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Polymerization on Solid Supports
Author(s) -
Li Xiaoyu,
Lynn David G.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021202)41:23<4567::aid-anie4567>3.0.co;2-6
Subject(s) - polymerization , dna , solid phase synthesis , polymer , histone octamer , dna synthesis , materials science , combinatorial chemistry , nanotechnology , chemistry , chemical engineering , biochemistry , peptide , engineering , nucleosome , histone , composite material
A powerful strategy to translate DNA directly into synthetic polymers: A solid‐phase synthetic strategy is applied to DNA‐templated synthesis by using immobilized native DNA octamer S(dA p ) 8 as a template to direct the specific polymerization of synthetic DNA analogues (T) 1 and (T N ) 2 (see figure). The solid‐supported template provides advantages in chemical amplification and purification.