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Facile Assembly of Cell Surface Oligosaccharide Mimics by Copolymerization of Carbohydrate Modules
Author(s) -
Sasaki Kenji,
Nishida Yoshihiro,
Tsurumi Tomoaki,
Uzawa Hirotaka,
Kondo Hirosato,
Kobayashi Kazukiyo
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021202)41:23<4463::aid-anie4463>3.0.co;2-#
Subject(s) - oligosaccharide , copolymer , carbohydrate , chemistry , polymer chemistry , materials science , biochemistry , organic chemistry , polymer
A highly practical strategy for mimicking the synthesis of cell‐surface oligosaccharides involves the segmentation of a given oligosaccharide into polymerizable carbohydrate modules containing two glycoside residues (A1 and A2) that provide key binding interactions with the receptor protein at the r (A1) and r (A2) binding sites. The bioactive structures are then regenerated by radical copolymerization.