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Formation of a Class of Enzyme Inhibitors (Drugs), Including a Chiral Compound, by Using Imprinted Polymers or Biomolecules as Molecular‐Scale Reaction Vessels
Author(s) -
Yu Yihua,
Ye Lei,
Haupt Karsten,
Mosbach Klaus
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021202)41:23<4459::aid-anie4459>3.0.co;2-2
Subject(s) - molecularly imprinted polymer , biomolecule , combinatorial chemistry , context (archaeology) , molecular recognition , polymer , polymerization , molecular imprinting , enantiomer , molecule , nanotechnology , materials science , chemistry , monomer , small molecule , organic chemistry , biology , catalysis , biochemistry , selectivity , paleontology
Two mutually complementary, target‐directed synthetic approaches have been used to generate a class of bio‐effective molecules (inhibitors). In the first, condensation reactions were performed within the cavities of a molecularly imprinted polymer (MIP) prepared against a known kallikrein inhibitor. In the second approach, the enzyme itself directed the assembly of small building blocks within the biologically active site (see scheme).