Formation of a Class of Enzyme Inhibitors (Drugs), Including a Chiral Compound, by Using Imprinted Polymers or Biomolecules as Molecular‐Scale Reaction Vessels | Zendy

Yu Yihua | Zendy; Ye Lei | Zendy; Haupt Karsten | Zendy; Mosbach Klaus | Zendy

Premium

Formation of a Class of Enzyme Inhibitors (Drugs), Including a Chiral Compound, by Using Imprinted Polymers or Biomolecules as Molecular‐Scale Reaction Vessels

Author(s) -

Yu Yihua,

Ye Lei,

Haupt Karsten,

Mosbach Klaus

Publication year - 2002

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/1521-3773(20021202)41:23<4459::aid-anie4459>3.0.co;2-2

Subject(s) - molecularly imprinted polymer , biomolecule , combinatorial chemistry , context (archaeology) , molecular recognition , polymer , polymerization , molecular imprinting , enantiomer , molecule , nanotechnology , materials science , chemistry , monomer , small molecule , organic chemistry , biology , catalysis , biochemistry , selectivity , paleontology

Two mutually complementary, target‐directed synthetic approaches have been used to generate a class of bio‐effective molecules (inhibitors). In the first, condensation reactions were performed within the cavities of a molecularly imprinted polymer (MIP) prepared against a known kallikrein inhibitor. In the second approach, the enzyme itself directed the assembly of small building blocks within the biologically active site (see scheme).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research