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Novel pH‐Reporter MRI Contrast Agents
Author(s) -
Aime Silvio,
Delli Castelli Daniela,
Terreno Enzo
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021115)41:22<4334::aid-anie4334>3.0.co;2-1
Subject(s) - contrast (vision) , chemistry , computer science , artificial intelligence
Attractive alternatives to conventional contrast agents for magnetic resonance imaging applications are the paramagnetic chemical exchange saturation transfer (CEST) agents based on saturation transfer (ST) to the solvent water resonance. The ratio of ST effects obtained upon irradiating Ln‐coordinated water and amide protons in [Ln(dotamGly)] (dotam=1,4,7,10‐tetrakis(carbamoylmethyl)‐1,4,7,10‐tetrazacyclododecane; see picture) complexes is pH dependent and concentration independent.