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A Five‐Component Synthesis of Hexasubstituted Benzene
Author(s) -
Janvier Pierre,
Bienaymé Hugues,
Zhu Jieping
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021115)41:22<4291::aid-anie4291>3.0.co;2-d
Subject(s) - benzene , component (thermodynamics) , domino , chemistry , transformation (genetics) , combinatorial chemistry , organic chemistry , catalysis , physics , thermodynamics , biochemistry , gene
Seven functional groups are involved in a highly ordered five‐component domino process, which leads to a biologically relevant polyheterocycle. In this one‐pot transformation, the formation of seven chemical bonds provides a hexasubstituted benzene core (see scheme; CSA = camphorsulfonic acid).