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The “Aryne” Route to Biaryls Featuring Uncommon Substituent Patterns
Author(s) -
Leroux Frédéric,
Schlosser Manfred
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021115)41:22<4272::aid-anie4272>3.0.co;2-b
Subject(s) - aryne , substituent , aryl , catalysis , chemistry , combinatorial chemistry , coupling (piping) , computational chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , alkyl , metallurgy
1,2‐Didehydroarenes (“arynes”) mediate as extremely reactive, short‐lived intermediates in selective aryl–aryl coupling processes to form biaryls with unprecedented substituent patterns (see scheme, X=H, F, Cl). Possible applications include the synthesis of novel ligands for asymmetric catalysis.