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The First Total Synthesis of Efrapeptin C
Author(s) -
Jost Micha,
Greie JörgChristian,
Stemmer Nina,
Wilking Sven David,
Altendorf Karlheinz,
Sewald Norbert
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021115)41:22<4267::aid-anie4267>3.0.co;2-k
Subject(s) - class (philosophy) , peptide synthesis , peptide , combinatorial chemistry , computer science , solid phase synthesis , phase (matter) , chemistry , content (measure theory) , stereochemistry , computational biology , biochemistry , organic chemistry , biology , artificial intelligence , mathematics , mathematical analysis
Synthetically challenging , the efrapeptins are a class of peptide antibiotics rich in α,α‐dialkylated amino acids. Efrapeptin C (see picture) was synthesized for the first time by a combination of solution‐phase and solid‐phase peptide synthesis steps with segment condensations.