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Enzymatic Elongation of the LEC14 Antigen Generates a β‐1,2 Arm on N ‐Glycans
Author(s) -
Prahl Ingo,
Unverzagt Carlo
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021115)41:22<4259::aid-anie4259>3.0.co;2-a
Subject(s) - glycan , oligosaccharide , enzyme , antigen , chemistry , glycosylation , biochemistry , elongation , stereochemistry , microbiology and biotechnology , biology , glycoprotein , immunology , materials science , ultimate tensile strength , metallurgy
Three arms carry more than two : By the total synthesis of the entire oligosaccharide, the proposed structure of the LEC14 antigen from a CHO cell line was confirmed. Surprisingly, enzymatic galactosylation of LEC14 gave the shown compound, which has a novel three‐armed structural motif.