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pH‐Responsive Molecular Nanocarriers Based on Dendritic Core‐Shell Architectures
Author(s) -
Krämer Michael,
Stumbé JeanFrançois,
Türk Holger,
Krause Simon,
Komp Ansgar,
Delineau Lydie,
Prokhorova Svetlana,
Kautz Holger,
Haag Rainer
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021115)41:22<4252::aid-anie4252>3.0.co;2-f
Subject(s) - nanocarriers , nanotechnology , drug delivery , polymer , chemistry , molecule , materials science , combinatorial chemistry , organic chemistry
A simple and efficient concept has been developed for the synthesis of pH‐responsive molecular nanocarriers based on commercially available hyperbranched polymers. These dendritic core‐shell architectures can encapsulate, transport, and selectively release polar guest molecules in an acidic environment (pH 3–6, see scheme). The observed release properties render these molecular nanocarriers promising candidates for controlled drug and gene delivery.