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First De Novo Synthesis of the Bisindole Alkaloid Vinblastine
Author(s) -
Schneider Christoph
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021115)41:22<4217::aid-anie4217>3.0.co;2-u
Subject(s) - vinblastine , alkaloid , stereochemistry , chemistry , combinatorial chemistry , biology , genetics , chemotherapy
More than 40 years after the isolation of vinblastine ( 1 ), and after considerable synthetic effort, Fukuyama et al. have now successfully completed the first de novo synthesis of this bisindole alkaloid and tumor therapeutic agent. Thus, not only should the synthesis of analogues and potentially more active compounds be possible, but the methods developed during the course of the synthesis should also expand the repertoire of the synthetic chemist.