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Cobalt‐Catalyzed Coupling Reaction of Alkyl Halides with Allylic Grignard Reagents
Author(s) -
Tsuji Takashi,
Yorimitsu Hideki,
Oshima Koichiro
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021104)41:21<4137::aid-anie4137>3.0.co;2-0
Subject(s) - halide , catalysis , allylic rearrangement , alkyl , reagent , cobalt , chemistry , coupling reaction , coupling (piping) , organic chemistry , materials science , metallurgy
Facile construction of quaternary carbon centers : The cobalt‐catalyzed coupling reaction of not only primary and secondary but also tertiary alkyl halides with allylic Grignard reagents proceeds smoothly (see scheme; dppp=1,3‐bis(diphenylphosphanyl)propane; R=primary, secondary, or tertiary alkyl group). A radical mechanism is proposed for the oxidative addition of alkyl halides to cobalt.