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Palladium‐Catalyzed Coupling of Alkyl Chlorides and Grignard Reagents
Author(s) -
Frisch Anja C.,
Shaikh Nadim,
Zapf Alexander,
Beller Matthias
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021104)41:21<4056::aid-anie4056>3.0.co;2-8
Subject(s) - palladium , catalysis , alkyl , reagent , coupling (piping) , chemistry , organic chemistry , combinatorial chemistry , materials science , metallurgy
Chloroalkanes refined : A simple catalyst system renders the palladium‐catalyzed coupling reaction of functionalized alkyl chlorides and Grignard reagents at room temperature (see example in scheme; PCy 3 =tricyclohexylphosphane, NMP= N ‐methylpyrrolidinone).