Premium
Highly Efficient Catalytic Synthesis of Substituted Allenes Using Indium
Author(s) -
Lee Kooyeon,
Seomoon Dong,
Lee Phil Ho
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021018)41:20<3901::aid-anie3901>3.0.co;2-s
Subject(s) - chemoselectivity , regioselectivity , propargyl , electrophile , catalysis , chemistry , indium , combinatorial chemistry , propargyl bromide , organic chemistry
Versatile, convenient, mild : Allenylindium intermediates generated from the reaction of indium with propargyl bromides were employed as effective coupling partners in Pd‐catalyzed cross‐coupling reactions with a variety of electrophiles to produce allenes, polyallenes, and unsymmetrical bis(allenes) in excellent yields with complete regioselectivity and chemoselectivity (see scheme for one example).