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Enantioselective Synthesis of Substituted Pyrrolidines by Dynamic Resolution
Author(s) -
Coldham Iain,
Dufour Samuel,
Haxell Thomas F. N.,
Howard Steven,
Vennall Graham P.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021018)41:20<3887::aid-anie3887>3.0.co;2-j
Subject(s) - enantioselective synthesis , electrophile , allylic rearrangement , resolution (logic) , chemistry , chiral ligand , ligand (biochemistry) , combinatorial chemistry , kinetic resolution , organic chemistry , catalysis , computer science , receptor , biochemistry , artificial intelligence
Not restricted to allylic or benzylic derivatives : The dynamic resolution of chiral organolithium species in the presence of a chiral ligand, L*, followed by addition of an electrophile, E + (see scheme), has been shown to occur with excellent enantioselectivity at ambient temperature by using nonactivated 2‐lithiopyrrolidines.