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A New Method for the Synthesis of Nonsymmetrical Sulfamides Using Burgess‐Type Reagents
Author(s) -
Nicolaou K. C.,
Longbottom Deborah A.,
Snyder Scott A.,
Nalbanadian Annie Z.,
Huang Xianhai
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021018)41:20<3866::aid-anie3866>3.0.co;2-t
Subject(s) - sulfamide , reagent , combinatorial chemistry , chemistry , simple (philosophy) , organic chemistry , epistemology , philosophy
A practical and high‐yielding method for the efficient, one‐step synthesis of diverse classes of N , N ′‐differentiated sulfamides has been developed from a wide range of amino alcohols and simple amines using Burgess‐type reagents (see scheme). This method enables the possible differentiation of both sides of any cyclic sulfamide product.