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Noncovalent Chemistry of Nitrous Oxide: Interactions with Secondary cis Amides in Solution
Author(s) -
Zyryanov Grigory V.,
Hampe Erin M.,
Rudkevich Dmitry M.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021018)41:20<3854::aid-anie3854>3.0.co;2-6
Subject(s) - chemistry , hydrogen bond , chloroform , non covalent interactions , nitrous oxide , hydrophobic effect , molecule , oxide , computational chemistry , hydrogen , organic chemistry , combinatorial chemistry
Is hydrogen bonding between N 2 O and amides and peptides possible? Secondary cis amides and N 2 O were found to interact in chloroform through hydrogen bonds and electrostatic interactions. In the absence of competing water molecules, such interactions may take place in hydrophobic enzyme pockets and in biological fluids, and may be responsible for a physiological activity of this gas.