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Methyl Transfer from Rhenium to Coordinated Thiolate Groups
Author(s) -
Shan Xiaopeng,
Ellern Arkady,
Espenson James H.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021018)41:20<3807::aid-anie3807>3.0.co;2-z
Subject(s) - rhenium , chemistry , nucleophile , ligand (biochemistry) , condensation , stereochemistry , group (periodic table) , methylation , medicinal chemistry , combinatorial chemistry , computer science , organic chemistry , catalysis , physics , receptor , biochemistry , thermodynamics , gene
Methylation of a thiolate group , which has only been observed in vitamin B 12 and its mimics, has been accomplished with [MeReO 3 ] and [MeReO(edt)PPh 3 ] (edt=1,2‐ethanedithiolato; see scheme). The proposed mechanism involves the formation of [MeRe VII O(edt) 2 ] through two stepwise condensation reactions; nucleophilic attack of a thiolate ligand on the methyl group leads to the product.