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Stereocontrolled Total Synthesis of Apicularen A and Its Δ 17,18 Z Isomer
Author(s) -
Nicolaou K. C.,
Kim David W.,
Baati Rachid
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021004)41:19<3701::aid-anie3701>3.0.co;2-4
Subject(s) - ozonolysis , carbon skeleton , total synthesis , skeleton (computer programming) , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , computer science , programming language
Mimicking nature's biosynthetic pathway to polyketides, a two‐step procedure involving allylation followed by ozonolysis was applied five times in total for the construction of the carbon skeleton of apicularen A ( 1 ). Application of the developed synthetic technology also establishes an entry into designed apicularen analogues.