Premium
A Simple, Reliable, Catalytic Asymmetric Allylation of Ketones
Author(s) -
Waltz Karen M.,
Gaveis Jason,
Walsh Patrick J.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021004)41:19<3697::aid-anie3697>3.0.co;2-u
Subject(s) - stereocenter , reagent , simple (philosophy) , catalysis , combinatorial chemistry , chemistry , class (philosophy) , process (computing) , organic chemistry , computer science , enantioselective synthesis , artificial intelligence , programming language , philosophy , epistemology
Allylation of ketones made easy : commercially available reagents can be used at room temperature to transform ketones into homoallylic alcohols with good to excellent enantioselectivities [Eq. (1)]. This process belongs to a rare class of reactions that catalytically form quaternary stereogenic centers.