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Exceptional Rate Enhancements and Improved Diastereoselectivities through Chelating Diamide Coordination in Intramolecular Alkene Hydroaminations Catalyzed by Yttrium and Neodymium Amido Complexes
Author(s) -
Kim Young Kwan,
Livinghouse Tom
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20021004)41:19<3645::aid-anie3645>3.0.co;2-f
Subject(s) - hydroamination , alkene , intramolecular force , chelation , chemistry , trimethylsilyl , catalysis , steric effects , amine gas treating , yttrium , combinatorial chemistry , medicinal chemistry , polymer chemistry , organic chemistry , oxide
Modification of the metal center in the complexes [Ln{N(TMS) 2 } 3 ] (Ln=Y, Nd; TMS=trimethylsilyl) is readily achieved by amine elimination in the presence of sterically hindered chelating diamines to provide complexes with substantially augmented catalytic activities and improved stereoselectivities in intramolecular alkene hydroamination (see scheme).