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A Pyridylsilyl Group Expands the Scope of Catalytic Intermolecular Pauson–Khand Reactions
Author(s) -
Itami Kenichiro,
Mitsudo Koichi,
Yoshida Junichi
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020916)41:18<3481::aid-anie3481>3.0.co;2-x
Subject(s) - intermolecular force , cyclopentenone , regioselectivity , chemistry , silylation , scope (computer science) , catalysis , group (periodic table) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , molecule , computer science , programming language
Now even unstrained alkenes can be used in catalytic intermolecular Pauson–Khand reactions [Eq. (a)]. This is made possible by the use of the directing group dimethyl(2‐pyridyl)silyl, which can be easily removed at the end of the reaction. Furthermore, one observes completely regioselective incorporation of substituents at the 4‐ and 5‐positions of the 2‐cyclopentenone structure.