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Fluorobalhimycin—A New Chapter in Glycopeptide Antibiotic Research
Author(s) -
Weist Stefan,
Bister Bojan,
Puk Oliver,
Bischoff Daniel,
Pelzer Stefan,
Nicholson Graeme J.,
Wohlleben Wolfgang,
Jung Günther,
Süssmuth Roderich D.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020916)41:18<3383::aid-anie3383>3.0.co;2-r
Subject(s) - glycopeptide , glycopeptide antibiotic , antibiotics , vancomycin , chemistry , molecule , combinatorial chemistry , chlorine , fluorine , stereochemistry , organic chemistry , biochemistry , biology , bacteria , genetics , staphylococcus aureus
Mutasynthesis—a very potent tool? The two chlorine atoms attached to the aglycon of vancomycin‐type glycopeptide antibiotics (see structure) have considerable influence on the antibiotic activity of each compound. By combining molecular genetic methods and chemical synthesis these chlorine atoms can be replaced by fluorine atoms. The described approach may also be applicable to modifying other parts of the glycopeptide molecule.