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An Alkynylboronic Ester Annulation: Development of Synthetic Methods for Application to Diversity‐Oriented Organic Synthesis
Author(s) -
Micalizio Glenn C.,
Schreiber Stuart L.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020902)41:17<3272::aid-anie3272>3.0.co;2-c
Subject(s) - annulation , diversity (politics) , organic synthesis , combinatorial chemistry , biochemical engineering , computer science , organic chemistry , chemistry , engineering , sociology , anthropology , catalysis
Branched networks of reactions create variety in this synthesis of trisubstituted allenes and functionalized enones from readily available homoallylic alcohols in just two steps, by using a new alkynylboronic ester annulation (see scheme; Mes=2,4,6‐trimethylphenyl, Cy=cyclohexyl).