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A New Pd 0 –Cu I Bimetallic Catalyst for the Synthesis of Indoles from Isocyanates and Allyl Carbonates
Author(s) -
Kamijo Shin,
Yamamoto Yoshinori
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020902)41:17<3230::aid-anie3230>3.0.co;2-w
Subject(s) - bimetallic strip , catalysis , chemistry , medicinal chemistry , lewis acids and bases , organic chemistry , combinatorial chemistry
Carboamination of alkynes is catalyzed by a Pd 0 –Cu I bimetallic species. The Pd 0 species act as a precursor for a π‐allylpalladium intermediate while the Cu I centers behave as a Lewis acid for CC bonds. This catalyst allows the synthesis of indoles from isocyanates and allyl carbonates (see scheme).