Premium
Stereoselective Synthesis of Tri‐ and Tetrasubstituted Olefins by Tandem Cyclization Addition Reactions Featuring Vinyl Radicals
Author(s) -
Gansäuer Andreas,
Pierobon Marianna,
Bluhm Harald
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020902)41:17<3206::aid-anie3206>3.0.co;2-2
Subject(s) - intramolecular force , tandem , epoxide , stereoselectivity , radical , chemistry , combinatorial chemistry , ring (chemistry) , stereochemistry , catalysis , organic chemistry , materials science , composite material
Intramolecular CC bond formation based on a titanocene‐catalyzed epoxide ring opening selectively leads to tri‐ and tetrasubstituted olefins (see scheme). This represents an excellent method for the otherwise difficult synthesis of such compounds.