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Towards A DNA‐Like Duplex without Hydrogen‐Bonded Base Pairs
Author(s) -
Mathis Gérald,
Hunziker Jürg
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020902)41:17<3203::aid-anie3203>3.0.co;2-k
Subject(s) - stacking , duplex (building) , oligonucleotide , base pair , intramolecular force , chemistry , hydrogen bond , crystallography , dna , hydrogen , stereochemistry , molecule , organic chemistry , biochemistry
The inverse quadrupolar moments of the phenyl and pentafluorophenyl residues in the non‐hydrogen‐bonded, artificial base pair shown here promotes strong intramolecular stacking interactions in oligonucleotide duplexes. The greater the number of natural base pairs that are replaced by this novel pair, the higher the thermodynamic stability of the resulting oligonucleotide duplex if they are arranged in an alternating fashion.