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A Structural and Functional Model of Galactose Oxidase: Control of the One‐Electron Oxidized Active Form through Two Differentiated Phenolic Arms in a Tripodal Ligand
Author(s) -
Thomas Fabrice,
Gellon Gisèle,
GautierLuneau Isabelle,
SaintAman Eric,
Pierre JeanLouis
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020816)41:16<3047::aid-anie3047>3.0.co;2-w
Subject(s) - galactose oxidase , chemistry , ligand (biochemistry) , galactose , stereochemistry , biochemistry , receptor
The axial phenol group is protonated and the equatorial phenoxyl group antiferromagnetically coupled to the cupric center in the complex [Cu II (LH)(OAc)] .+ (see picture), which can be considered as both a structural and functional model of galactose oxidase. This complex reproduces the features of the enzyme chemistry. The phenoxyl radical position (equatorial versus axial) is dictated by protonation.