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Combinatorial and Rational Strategies To Develop Nonpeptidic α4β7‐Integrin Antagonists from Cyclic Peptides
Author(s) -
Gottschling Dirk,
Boer Jürgen,
Schuster Anja,
Holzmann Bernhard,
Kessler Horst
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020816)41:16<3007::aid-anie3007>3.0.co;2-3
Subject(s) - addressin , integrin , dipeptide , chemistry , rational design , cyclic peptide , computational biology , peptide , biochemistry , stereochemistry , combinatorial chemistry , cell , biology , genetics
Non‐peptidic compounds (e.g. 2 ) derived from cyclic peptides such as 1 are able to inhibit the α4β7‐integrin/MAdCAM‐1 interaction. 3‐Amino arylpropionic acids are valuable dipeptide mimetics. MAdCAM‐1 = mucosal addressin cell‐adhesion molecule 1.