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Trifluoroacetophenone Derivatives as Amino Acid Selective Ionophores for the Potentiometric Determination of Phenylalanine
Author(s) -
Sasaki Shinichi,
Hashizume Akio,
Citterio Daniel,
Fujii Eiji,
Suzuki Koji
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020816)41:16<3005::aid-anie3005>3.0.co;2-f
Subject(s) - christian ministry , potentiometric titration , chemistry , phenylalanine , cationic polymerization , amino acid , ion selective electrode , benzene , membrane , combinatorial chemistry , selectivity , organic chemistry , ion , biochemistry , political science , law , catalysis
Selective sensors : Trifluoroacetophenone derivatives were synthesized with a hexasubstituted benzene ring as a preorganized spacer (see scheme) and their characteristics as ionophores were examined for use in ion‐selective electrodes. The electrode membranes based on these neutral carriers combined with a cationic additive showed a monoanionic Nernstian response to underivatized phenylalanine, with excellent selectivity towards other essential amino acids and inorganic anions.