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Rhenium( VII ) Oxo Complexes as Extremely Active Catalysts in the Dehydration of Primary Amides and Aldoximes to Nitriles
Author(s) -
Ishihara Kazuaki,
Furuya Yoshiro,
Yamamoto Hisashi
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020816)41:16<2983::aid-anie2983>3.0.co;2-x
Subject(s) - dehydration , rhenium , chemistry , primary (astronomy) , catalysis , organic chemistry , medicinal chemistry , biochemistry , physics , astronomy
An economical and environmentally benign process for the preparation of nitriles by the dehydration of primary amides and aldoximes is catalyzed by rhenium( VII ) oxo complexes such as perrhenic acid and trimethylsilylperrhenate (see scheme). The reaction proceeds at azeotropic reflux (with the removal of water) under essentially neutral conditions.