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Micelles and Hollow Nanospheres Based on ε ‐Caprolactone‐Containing Polymers in Aqueous Media
Author(s) -
Liu Xiaoya,
Jiang Ming,
Yang Shuli,
Chen Mingqing,
Chen Daoyong,
Yang Cheng,
Wu Kang
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020816)41:16<2950::aid-anie2950>3.0.co;2-k
Subject(s) - copolymer , caprolactone , micelle , polymer chemistry , aqueous medium , polymer , chemical engineering , aqueous solution , christian ministry , materials science , amphiphile , polymer science , chemistry , organic chemistry , philosophy , theology , engineering
A block‐copolymer‐free strategy has been used to form micelles by the self‐assembly of poly( ε ‐caprolactone) (PCL) and a graftlike copolymer which has a hydrophilic backbone and short PCL side‐chains (see schematic representation). Affinity between the PCL homopolymer and the PCL short branches appears to stabilize the micelles. The hydrophobic polyester core can be selectively hydrolyzed by lipase to give hollow spheres, as shown by transmission electron microscopy.