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[Lewis Acid] + [Co(CO) 4 ] − Complexes: A Versatile Class of Catalysts for Carbonylative Ring Expansion of Epoxides and Aziridines
Author(s) -
Mahadevan Viswanath,
Getzler Yutan D. Y. L.,
Coates Geoffrey W.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020802)41:15<2781::aid-anie2781>3.0.co;2-s
Subject(s) - lewis acids and bases , carbonylation , chemistry , catalysis , yield (engineering) , ring (chemistry) , stereoselectivity , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , carbon monoxide , materials science , metallurgy
Efficient carbonyl insertion into CO and CN bonds using [Lewis acid] + [Co(CO) 4 ] − complexes 1 and 2 gives regio‐ and stereoselective carbonylation of a variety of epoxides and aziridines to yield β ‐lactones and β ‐lactams, respectively. Both transformations are proposed to occur by the same mechanism, yielding products with inversion of configuration at the site of CO insertion.