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[Ir 4 (CO) 12 ]‐Catalyzed Coupling Reaction of Imidazoles with Aldehydes in the Presence of a Hydrosilane to Give 2‐Substituted Imidazoles
Author(s) -
Fukumoto Yoshiya,
Sawada Katsutoshi,
Hagihara Motoyuki,
Chatani Naoto,
Murai Shinji
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020802)41:15<2779::aid-anie2779>3.0.co;2-j
Subject(s) - dimethyl acetylenedicarboxylate , yield (engineering) , catalysis , chemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , cycloaddition , materials science , metallurgy
A significant increase in yield is observed when DMAD is added to the reaction of 1‐methylimidazole ( 1 ) with aldehydes 2 and diethylmethylsilane in the presence of a catalytic amount of [Ir 4 (CO) 12 ] to produce 2‐(1‐diethylmethylsiloxyalkyl)imidazoles 3 . DMAD=dimethyl acetylenedicarboxylate.