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( E )‐4‐Hydroxy‐3‐methylbut‐2‐enyl Diphosphate: An Intermediate in the Formation of Terpenoids in Plant Chromoplasts
Author(s) -
Gao Wenyun,
Loeser Reik,
Raschke Maja,
Dessoy Marco A.,
Fulhorst Michael,
Alpermann Henriette,
Wessjohann Ludger A.,
Zenk Meinhart H.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020715)41:14<2604::aid-anie2604>3.0.co;2-s
Subject(s) - terpenoid , chromoplast , chemistry , stereochemistry , phytoene , phytoene synthase , farnesyl diphosphate synthase , biosynthesis , biochemistry , enzyme , plastid , gene , chloroplast
The missing link in the new deoxyxylulose phosphate metabolic pathway leading to the biosynthesis of plant terpenoids has been identified. The intermediate between the cyclic diphosphate 1 and the basic isoprenoid building blocks dimethylallyl diphosphate and isopentenyl diphosphate has been shown for the first time to be ( E )‐4‐hydroxy‐3‐methylbut‐2‐enyl diphosphate ( 2 ) by incorporation of tritium‐labeled 2 into phytoene.