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Anti‐Markovnikov Hydroamination of Terminal Alkynes
Author(s) -
Tillack Annegret,
Garcia Castro Ivette,
Hartung Christian G.,
Beller Matthias
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020715)41:14<2541::aid-anie2541>3.0.co;2-7
Subject(s) - markovnikov's rule , hydroamination , alkyne , chemistry , catalysis , alkyl , combinatorial chemistry , terminal (telecommunication) , regioselectivity , organic chemistry , telecommunications , computer science
Titanocene‐ η –alkyne complexes such as 1 are efficient catalysts for the hydroamination of terminal alkynes to imines (see scheme; R=alkyl, R′=SiMe 3 or Ph). Excellent yields of imines and good to excellent regioselectivities for the anti‐Markovnikov products were obtained.